Researchers led by Heba M. Abdou of Alexandria University, Egypt, have published a new scientific paper titled “Efficacy of Plasmalogens on Monosodium Glutamate-Induced Neurotoxicity in Male Rats Through NF-κB and p38 MAPK Signaling Pathways.”

In this preclinical study, the researchers used an MSG-induced rat model of neurotoxicity to investigate plasmalogens. Monosodium glutamate (MSG), a widely used food additive, has been associated in experimental studies, particularly at high doses, with neurotoxicity, oxidative stress, and inflammatory responses. The study evaluated oxidative stress and antioxidant markers, inflammatory responses, and histological changes in the hippocampus, as well as the NF-κB and p38 MAPK signaling pathways.

Journal: Oxidative Medicine and Cellular Longevity.2025; Article ID 3673280.
Authors: Heba M. Abdou, Fatma A. Hamaad, Ghada M. Abd Elmageed, Hideki Katano, Mamdooh H. Ghoneum.