A new scientific paper entitled “Efficacy of Plasmalogens on Monosodium Glutamate-Induced Neurotoxicity in Male Rats Through NF-κB and p38 MAPK Signaling Pathways” has been published. The study was conducted by a research team led by Heba M. Abdou of Alexandria University, Egypt.

Monosodium glutamate (MSG) is a widely used food additive and has been associated in experimental studies with neurotoxicity, oxidative stress, and inflammatory responses. In this study, researchers used an MSG-induced rat model of neurotoxicity to evaluate the potential protective effects of plasmalogens. The results showed that plasmalogen administration improved antioxidant status, reduced inflammatory markers, and attenuated hippocampal neuronal damage caused by MSG exposure. These findings suggest that plasmalogens may exert neuroprotective effects through antioxidant and anti-inflammatory actions, as well as modulation of the NF-κB and p38 MAPK signaling pathways.

Journal: Oxidative Medicine and Cellular Longevity (2025), Article ID 3673280
Authors: Heba M. Abdou, Fatma A. Hamaad, Ghada M. Abd Elmageed, Hideki Katano, Mamdooh H. Ghoneum