Products
Click here for more information.
- Published Research Papers
- Academic Presentations
| 2025 | Plasmalogen as a Bioactive Lipid Drug: From Preclinical Research Challenges to Opportunities in Nanomedicine Wu Y, Deng Y, Angelov B, Angelova A. FASEB Bioadv. 2025 Jun 4;7(8):e70028. doi:10.1096/fba.2025-00010. |
|---|---|
| 2025 | Plasmalogen-Containing Scallop-Derived Lipids Affect the Endocrine System of Caenorhabditis elegans Nematodes and Improved Its Lifespan and Health Riku Inoue, Kazuichi Sakamoto. Food and Nutrition Sciences. 2025 June;16(6):729-740. doi:10.4236/fns.2025.166040. |
| 2024 | Comparison of Daiwa Brain Health (Hokkaido Scallop Oil Plasmalogen) and Prevagen (Apoaequorin) on Cognitive Function: An In-Office Pilot Study Pescatore F. Altern Ther Health Med. 2024 Oct;30(10):18-20. |
| 2024 | Lipid and Transcriptional Regulation in a Parkinson's Disease Mouse Model by Intranasal Vesicular and Hexosomal Plasmalogen-Based Nanomedicines Wu Y, Wang J, Deng Y, Angelov B, Fujino T, Hossain MS, Angelova A. Adv Healthc Mater. 2024 Jun;13(14):e2304588. doi:10.1002/adhm.202304588. |
| 2023 | Protective effect of scallop-derived plasmalogen against vascular dysfunction, via the pSTAT3/PIM1/NFATc1 axis, in a novel mouse model of Alzheimer's disease with cerebral hypoperfusion Yun Zhai, Ryuta Morihara, Tian Feng, Xinran Hu, Yusuke Fukui et al. Brain Res. 2024 Apr 1;1828:148790. doi:10.1016/j.brainres.2024.148790. |
| 2023 | The Effects of HSOP on Cognition, Depression, and Activities of Daily Living in Older Adults with Cognitive Issues John E. Lewis, Lonnie A. Fravel. TOWNSEND LETTER The Examiner of Alternative Medicine. 2023 March 1. |
| 2022 | The Effects of HSOP on Cognition, Depression, and Activities of Daily Living in Older Adults with Cognitive Issues Lewis JE, Fravel LA. Integr Med (Encinitas). 2022 Dec;21(6):16-20. |
| 2022 | Ethanolamine plasmalogens derived from scallops stimulate both follicle-stimulating hormone and luteinizing hormone secretion by bovine gonadotrophs Hiroya Kadokawa, Miyako Kotaniguchi, Shiro Mawatari, Risa Saito, Takehiko Fujino, Shinichi Kitamura. Sci Rep. 2022 Oct 6;12(1):16789. doi:10.1038/s41598-022-20794-4. |
| 2022 | Orally Administered Plasmalogens Alleviate Negative Mood States and Enhance Mental Concentration: A Randomized, Double-Blind, Placebo-Controlled Trial Minoru Fujino, Jun Fukuda, Hirohisa Isogai, Tetsuro Ogaki, Shiro Mawatari et al. Front Cell Dev Biol. 2022 Jun 2;10:894734. doi:10.3389/fcell.2022.894734. |
| 2022 | Clinical and Pathological Benefits of Scallop-Derived Plasmalogen in a Novel Mouse Model of Alzheimer's Disease with Chronic Cerebral Hypoperfusion Tian Feng, Xinran Hu, Yusuke Fukui, Zhihong Bian, Yuting Bian et al. J Alzheimers Dis. 2022;86(4):1973-1982. doi:10.3233/JAD-215246. |
| 2022 | The Effects of HSOP on Cognition, Depression, and Activities of Daily Living in Older Adults with Cognitive Issues John E Lewis, Lonnie A Fravel Integr Med (Encinitas). 2022 Dec;21(6):16–20. |
| 2022 | Plasmalogens, the vinyl ether-linked glycerophospholipids, enhance learning and memory by regulating brain-derived neurotrophic factor Chao Huang, Fuping Zhang, Zhengyi Xu, Jianming Wei. Sensors (Basel). 2022 Feb 21;22(4):1678. doi:10.3390/s22041678. |
| 2022 | The Effect of HSOP (Hokkaido Scallop Oil Plasmalogen) on POMS2 Test Score Naoki Igari, Kentaro Ninomiya, Hideki Katano. TOWNSEND LETTER – FEBRUARY/MARCH. 2022;60:62-63. |
| 2021 | Neuroprotective effects of Scallop-derived plasmalogen in a mouse model of ischemic stroke Tian Feng, Xinran Hu, Yusuke Fukui, Koh Tadokoro, Zhihong Bian et al. Brain Res. 2021 Sep 1;1766:147516. doi:10.1016/j.brainres.2021.147516. |
| 2021 | Therapeutic Efficacy of Plasmalogens for Alzheimer's Disease, Mild Cognitive Impairment, and Parkinson's Disease in Conjunction with a New Hypothesis for the Etiology of Alzheimer's Disease Takehiko Fujino, Md Shamim Hossain, Shiro Mawatari. Adv Exp Med Biol. 2020;1299:195-212. doi:10.1007/978-3-030-60204-8_14. |
| 2020 | Improvement of blood plasmalogens and clinical symptoms in Parkinson's disease by oral administration of ether phospholipids: A preliminary report Shiro Mawatari, Shinji Ohara, Yoshihide Taniwaki, Yoshio Tsuboi, Toru Maruyama, Takehiko Fujino. Parkinsons Dis. 2020 Feb 19;2020:2671070. doi:10.1155/2020/2671070. |
| 2019 | Plasmalogens and Alzheimer's disease: a review Su XQ, Wang J, Sinclair AJ. Lipids Health Dis. 2019 Apr 16;18(1):100. doi: 10.1186/s12944-019-1044-1. |
| 2018 | Plasmalogens Inhibit Endocytosis of Toll-like Receptor 4 to Attenuate the Inflammatory Signal in Microglial Cells Fatma Ali, Md Shamim Hossain, Sanyu Sejimo, Koichi Akashi. Mol Neurobiol. 2019 May;56(5):3404-3419. doi:10.1007/s12035-018-1307-2. |
| 2018 | Effects of Plasmalogen on Patients with Mild Cognitive Impairment (MCI) Takehiko Fujino, Tatsuo Yamada, Takashi Asada, Midori Ichimaru, Yoshio Tsuboi et al. J Alzheimers Dis Parkinsonism. 2018;8(1):419. doi:10.4172/2161-0460.1000419 |
| 2017 | Efficacy and blood plasmalogen changes by oral administration of plasmalogen in patients with mild Alzheimer's disease and mild cognitive impairment: a multicenter, randomized, double-blind, placebo-controlled trial Takehiko Fujino, Tatsuo Yamada, Takashi Asada, Yoshio Tsuboi, Chikako Wakana et al. EBioMedicine. 2017 Mar;17:199-205. doi:10.1016/j.ebiom.2017.02.012. |
| 2004 | Fatty acids of serine, ethanolamine, and choline plasmalogens in some marine bivalves Edouard Kraffe, Philippe Soudant, Yanic Marty. Lipids. 2004 Jan;39(1):59-66. doi:10.1007/s11745-004-1202-x. |