Identification of proteases derived from Bacillus subtilis var. natto related to thrombolysis

　　　　　　　　　

The thrombolytic effect of NKCP is attributable to a proteolytic enzyme named bacillopeptidase F, produced by Bacillus subtilis var. natto. Bacillopeptidase F is shown to be one of five proteases produced and secreted by Bacillus natto (Table 1).

“1)Journal of Bacteriology 1990; 172: 1019-1023 2)The Journal of Biological Chemistry 1990; 265: 6845-6850 3)Journal of Bacteriology 1990; 172: 1470-1477 4)Experientia 1987; 43: 1110-1111 5)The Journal of Biological Chemistry 2001; 276: 24690-24696 6)Mol Gen Genet 1990 May; 221(3): 486-490”