Antihyperglycemic effect

The antihyperglycemic effect of orally administered Kefiran was examined using spontaneously diabetic 8-week-old male KKAy mice. The treatment lasted for 30 days. Blood glucose levels were measured before treatment and at days 15 and 30. After the start of treatment, chronological changes in blood glucose levels at satiety measured at days 15 and 30 showed that the control group mice were hyperglycemic throughout the study. However, in the two groups receiving Kefiran, suppression of blood sugar elevation was observed at days 15 and 30. On day 30, the group administered 300 mg/kg of Kefiran showed significantly lower spikes. In a manner similar to the satiety test, the fasting blood sugar levels also showed lower values for the two groups treated with Kefiran as compared to the control group.

Maeda H., Zhu X. and T. Mitsuoka. 2004. “Effects of an Exopolysaccharide (Kefiran) from Lactobacillus kefiranofaciens on Blood Glucose in KKAy Mice and Constipation in SD Rats Induced by a Low-Fiber Diet”, Bioscience and Microflora, 23(4), 149-153