Effects of HSOP Supplementation on Cognitive Function in Older Adults

Integrative Medicine. Vol.21, No.6, January 2023, 16-20
John E. Lewis and Lonnie A. Fravel

Nine older adults with cognitive issues received HSOP capsules containing 0.5 mg of scallop-derived plasmalogen (1–2 capsules per day) for 90 days. Changes in cognitive and functional status were evaluated using four assessment scales: ADL (Activities of Daily Living), IADL (Instrumental Activities of Daily Living), CES-D (Center for Epidemiologic Studies Depression Scale), and MMSE (Mini-Mental State Examination).
After supplementation, MMSE scores improved in five of seven participants, with one showing no change and one showing a decline. The mean MMSE score increased significantly from 19.1 to 21.9 (p = 0.04). No significant changes were observed in the other scales, although CES-D scores improved in five of six participants. These results suggest that HSOP capsules are safe and well tolerated and may help support cognitive function and prevent low mood in older adults.