Influence on liver damage

H. Sanada and Y. Egashira
7th meeting of the Japanese Association for Dietary Fiber Research, Tokyo, 2002

Male Wistar rats (5 rats/group) were administered 800 mg/kg D-galactosamine intraperitoneally to induce liver damage. Serum GOT and GPT were determined 24 hours after the administration of D-galactosamine, as induces of liver damage. One hour before administration of D-galactosamine, 20, 40, or 80 mg/kg of BioBran was administered intraperitoneally.
The serum AST(GOT) and ALT(GPT) in the control group without BioBran at 24 hours after the administration of D-galactosamine were 1410 IU/L and 445 IU/L, respectively. Compared to these values, serum GOT and GPT in the groups treated with BioBran were significantly lower at all doses.

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