Daiwa Pharmaceutical Holds "The International BioBran Workshop 2009"

Daiwa Pharmaceutical Holds "The International BioBran Workshop 2009"

Daiwa Pharmaceutical held "The International BioBran Workshop 2009" at Kokuyo Hall in Tokyo on August 2, 2009 (Sunday). (Sponsored by CMP Japan Co., Ltd., Food Chemical News Co., Ltd., Kenkosangyoryutsu-shinbunsha, and Health Business Magazine Co., Ltd.) Our main product, "BioBran," has already been used in 46 countries worldwide, and there have been over 30 articles and 50 and more academic presentations on "BioBran". In this workshop, doctors from Japan, the U.S., Slovakia, Thailand, Indonesia, Australia, and Philippines presented clinical reports. One of these was Dr. Ghoneum, who is one of the developers of BioBran. More than 350 people including over 60 doctors and researchers from overseas attended the workshop. The workshop had three parts (Session 1 to Session 3). The content of each report is summarized below:

Session 1
“Cancer and Immunity; An update with an emphasis on NK cells”

MGN-3/Bio Bran : A Safe Way to Fight Hepatocellular Carcinoma and Hepatitis B Virus, and Possible Mechanisms Underlying its Effect Mamdooh　Ghoneum, Ph.D. （Drew University/UCLA School of Medicine, USA）

（Abstract） There is a disproportionately high incidence of Hepatocellular Carcinoma (HCC) in developing countries, and over 50% of HCC cases occur in Asia. Hepatitis B virus (HBV) is the most common serious liver infection in the world.
The current study suggests that MGN-3/BioBran is a safe way to fight cancer and infection, in particular HCC and HBV infection. The structure of MGN-3 compound is an arabinoxylan with a xylose in its main chain and an arabinose polymer in its side chain. A clinical study of the effect of MGN-3 against HBV infection was carried out in Vietnam. We conclude that MGN-3 may be useful for the treatment of HCC and HBV.

BioBran activates innate natural killer and dendritic cells
Dana　Cholujova，RNDr., Ph.D.　（Cancer　Research　Institute, Slovak Republic）

（Abstract）
Dendritic cells(DCs) play crucial roles as initiators and regulators of immune responses. The modulatory effects of BioBran on in vitro maturation of human DCs were studied. DCs were treated with different concentrations of BioBran in the presence or absence of relevant cytokine maturation mix to assess its effects on DC maturation. Dose-dependent stimulatory effect of BioBran on maturation of DCs was manifested.

The Effect of an Enhanced Rice Bran Nutritional Supplement on Immune System Function
John　E．Lewis, Ph.D. （Assistant Professor, University of Miami, USA）

（Abstract）
An overall research strategy utilizing BRM4 (BioBran) as the key treatment - A discussion of our present study, “The Effect of an Enhanced Rice Bran Nutritional Supplement on Immune System Function,” at the University of Miami will be presented as a model of our global approach to research. This global approach is to advance the state of BRM4 science in diseases where immuno-modulation can help improve the quality of life of patients.

Efficacy of SSM and BioBran (RBAC) on Immunological Response
Yoshihiro Fukuo, M.D. （Director, Hakujikai Institute of Garontology, Hakujikai Foundation, Japan）

（Abstract）
It is evident that the incidence of cancer is rising in the rapidly aging society of Japan.
In general, cancer is asymptomatic, taking 10 to 20 years for it to develop from the early stage at the cellular level to an advanced stage where various subjective symptoms manifest. Once such symptoms are evident, it is too late to eliminate the cancer completely. Maruyama Vaccine (SSM) is a well-known immunotherapy that enhances immunity. It has been administered to 360,000 patients thus far, and has shown beneficial benefits. It has been revealed that the active ingredient of SSM is arabinomannan.
It is suggested that the arabinomannan sugar chain modifies the receptor sugar chain of the MHC structure on T-cells, inducing immune resonance with NK cells.

Session 2 “Immunity and Anti-inflammation; New Potent Clinical Reports”

Therapeutic effect of BioBran (RBAC) on Irritable Bowel Syndrome (IBS)
Takeshi Kamiya, M.D., Ph.D. (Assistant Professor, Nagoya City University Graduate School of Medical Science)

（Abstract）
The pathology of irritable bowel syndrome (IBS) involves many factors that causes a variety of dysfunction via brain-gut interaction Recently, it was revealed that low grade mucosal inflammation and/or immune imbalance of the lower digestive tract is one of the mechanisms involved in symptom generation in patients with IBS.
BioBran, an arabinoxylan compound derived from rice bran, has been reported to have a variety of biological actions such as anti-inflammatory and immune modulatory effects. In this study, we examined the therapeutic effects of BioBran in IBS patients. The results of this study indicate that the administration of BioBran improved IBS symptoms. It is likely that anti-inflammatory and/or immune modulatory effects of BioBran is useful in patients with IBS.

Inhibitory Effect of BioBran (RBAC) on Hepatopathy induced by D-galactosamine in Rat
Yukari Egashira, D.Ag. (Professor, Graduate School of Horticulture. Chiba University, Japan)

（Abstract）
BioBran/MGN-3 is made through the action of the enzyme of Basidiomycetes on the rice bran hemicellulose, and has various physiological actions such as antitumor and immunomodulatory effects. On the other hand, it is known that exposure to D-garactosamine (D-GaIN) induces liver damage in rat.
We investigated the inhibitory effect of MGN-3 on D-GaIN-induced liver damage. As a result, experiment showed a significant reduction of IL-18 mRNA in the liver of the MGN-3 low molecular weight fraction group compared with the control group, 8 hours after D-GaIN administration. The above findings suggest that the innate immune system has some role in the inhibitory effect of the low molecular fraction of MGN-3 on hepatitis.

Immunosenescence Reversal, An Evidence-based Anti-Aging Study
Karriem H. Ali, M.D., Ph.D.　(Principal, CSO, Pharmacognosia, USA）

（Abstract）
The current scientific literature presents us with a vast body of evidence that identifies immune dysregulation as the determinative factor for the functional decline associated with advancing age. This dysregulation is termed Immunossenescence.
Our current research, and over a decade of prior studies, have established Rice Bran Arabonoxylan Compound (RBAC) as a safe and reliable, non-toxic, immunomodulator with significant anti-inflammatory properties. The RBAC Immunomodulator mode of action counters the destructive effects on Immunosenescence by restoring optimal immune function.

Session 3 “Panel Discussions; Worldwide clinical observations/Doctors' Opinions”

The following doctors presented the latest clinical reports on BioBran:
Taizo Hoshino, M.D.　　（Director, Premiere Clinic, Japan）
Kampon Sriwatanakul, M.D., Ph.D.　　　　（Thailand）
I Wayan Sudarsa, M.D.　（Indonesia）
Edna Sasing Lao, M.D.　　　　　　（Philippines）
Garth Harris, BSc.　　　　　　　　（Australia）

The panel discussion was chaired by Dr.. Yuzo Endo (First Department of Pathology, Hamamatsu University School of Medicine, Japan) and Dr. Karriem H. Ali. The above-mentioned 5 doctors participated in the discussion and actively exchanged opinions with doctors and researchers attending the workshop.

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