Daiwa Pharmaceutical Co.,Ltd.：BIOBRAN（Rice Bran Arabinoxylan Derivative）

2006 Jul. "In Vivo Tumor Inhibitory Effects of Arabinoxylan Rice Bran (MGN-3/biobran) on Ehrlich Carcinoma-Bearing Mice"
International Research Conference on Food and Cancer, Washington D.C.
Mamdooh Ghoneum,Nariman K.Badr El-Din,Eman Noaman,Sastry Gollapudi

Jun. "Effect of Modified Arabinoxylan from Rice Bran(MGN-3/Biobran)On Human Neutrophils and Monocyte Functions In Vitro."
Federation of Clinical Immunology Societies Annual Meeting, San Francisco
Mamdooh Ghoneum,Sastry Gollapudzi

2005 May "Improving effect of hydrolyzed rice bran on diabetic rats given high-carbohydrate feed"
The 59th Annual Meeting of the Japanese Society of Nutrition and Food Science, Tokyo University of Agriculture
Nao Kitamura, Ikuo Ohara et al.

2004 Nov. "Immunomodulatory Activity of Enzyme-treated Rice Bran Hemicellulose"
Japanese Association for　Dietary Fiber Research
Tomisato Miura (Hirosaki University, School of Medicine) and Yoji Kato (Faculty of Education, Hirosaki University)

Sep. "Hydrolyzed Rice Bran Reduces the Aggravation of Protein Metabolism in the Streptozotocin-Induced Diabetic Rats"
American College of Nutrition, 45^th Annual Meeting, Carifornia
Kitamura N., Ohara I. (Aichi Gakusen University) et al.

Sep. "Chemical Structure of Immunostimulating Substances from Rice Bran"
2004 Annual Meeting of the Japanese Society of Applied Glycoscience and 12th Symposium on Amylases and Related Enzymes, Kagoshima
Miura T, Chiba M., Miyazaki Y., Kato Y. (Hirosaki University) et al.

Aug. "Evaluation of the Effect of Hydrolyzed Rice Bran on Reducing Respiratory Symptom in the Smokers"
21^stSymposium of Medical and Pharmaceutical Society for WAKAN-YAKU, Toyama
Omura K. (Dokkyo University School of Medicine, Department of Legal Medicine), Kudo M., (Daiwa Pharmaceutical Co., Ltd.) N. Nakamichi (The Jikei University, N.S. Clinic) et al.

Aug. "The Oral Administration of Hydrolyzed Rice Bran Prevents the Common Cold Syndrome in the Elderly"
21^stSymposium of Medical and Pharmaceutical Society for WAKAN-YAKU, Toyama
Omura K. (Dokkyo University School of Medicine, Department of Legal Medicine), Ichihashi K. (Ichihashi Clinic), Fujie T. (Atreju Uosaki), Kudo M., Zhu X., (Daiwa Pharmaceutical Co., Ltd.) K. Tazawa (Toyama Medical and Pharmaceutical University) et al.

Jun. "Effect of the Oral Administration of Hydrolyzed Rice Bran (HRB) on the Common Cold Syndrome in the Elderly"
4^th Conference of Japanese Society of Anti-Aging Medicine, Tokyo
Omura K. (Dokkyo University School of Medicine), Ichihashi K. (Ichihashi Clinic), Tazawa (Toyama Medical and Pharmaceutical University)

Feb. "Modified arabinoxylan rice bran (MGN-3/Biobran) potentiates apoptosis in　cancer cells induced by multiple anti-cancer agents in vitro "
7^th International Symposium on Predictive Oncology & Intervention Strategies, Nice
Ghoneum M.（UCLA/Drew University）and S. Gollapudi（University of California Irvine）

2003 Dec. "Effect of Rice Bran Arabinoxylan and Shark Lipid Extract on Complementary and Alternative Therapy"
7^th Conference of Japanese Association for Alternative, Complementary and Traditional Medicine (JACT), Kobe
Omori T. (Ginza San Espero Omori Clinic)

Dec. "The effect in the physiological function of a Modified Arabinoxylan Rice Bran"
Japan Society for Biological Therapy, Toyama
Masada M. (Chiba University), K. Tazawa (Toyama Medical and Pharmaceutical University) et al.

Oct. "Immunoactivation therapy for various progressive cancers using rice bran arabinoxylan derivative (Bio Bran)"
The Japanese Society for Complementary and Alternative Medicine, Sendai
Tsunekawa H. (Tsunekawa Gastrointestinal Clinic) et al.

Oct. "A Novel Approach to Breast Cancer Therapy: Modified Arabinoxylan Rice Bran (MGN-3/Biobran) Enhances Apoptosis of Human Breast Cancer Cells Following Phagocytosis of Saccharomyces Cerevisiae, the Baker's Yeast, in vitro "
American Association for Cancer Research Special Conference in California Ghoneum M. (UCLA/Drew University) and S. Gollapudi (University of California Irvine)

2002 Nov. "A new approach to regulating cytokine production"
The 1st International Symposium of The Institute of Functional Biomaterials and Biotechnology, Korea
S. Nonoyama (National Defense Medical College)

Nov. "Evaluation of the effects of asthma prevention and symptom reduction by enzymatically modified rice-bran foods in asthmatic model mice"
52^nd Conference of Japanese Society of Allergology, Yokohama
Kanbayashi H. and Y. Endo (McMaster University)

Nov. "Significance of asthmatic mouse model exposed to antigen (Toluene Diisocyanate) for a prolonged period"
52^nd Conference of Japanese Society of Allergology, Yokohama
Kanbayashi H. and Y. Endo (Department of Pathological Molecular Medicine, McMaster University)

Nov. "Effect of Enzyme-processed Rice Bran Hemicellulose (MGN-3) on Experimental Liver Dysfunction in Rats"
7^th Conference of Japanese Association for Dietary Fiber Research, Tokyo
Yamada T., Daizou A., Poindoglun K. (Graduate School of Science and Technology, Chiba University), Egashira K., Sanada H. (Department of Bioresources Chemistry, Chiba University) et al.

Oct. "MGN-3 potentiates death receptor-induced apoptosis in cancer cells"
93^rd Annual Meeting 2003 of American Association for Cancer Research, Boston
Ghoneum M. (UCLA/Drew University) and S. Gollapudi (University of California Irvine)

Oct. "Normalization of the Lymphocyte System in Peripheric Blood Reaction by Arabinoxylan from Rice Bran (MGN-3)"
43^rd Annual Meeting, American College of Nutrition, San Antonio, Texas
Ueda Y., Masada M. (Department of Bioresources Chemistry, Chiba University) et al.

Mar. "The effect of modified rice-bran arabinoxylan on NK activity of human peripheral blood lymphocytes"
46^th Japan Society for Bioscience, Biotechnology and Agrochemistry, Sendai
Shimomura C. (Graduate School of Science and Technology, Chiba University), Ueda Y., Kodama H., Masada M. (Department of Bioresources Chemistry, Chiba University) et al.

Mar. "Study on the growth inhibiting component of cancerous cells in culture cell lines derived from modified rice-bran arabinoxylan"
46^th Japan Society for Bioscience, Biotechnology, and Agrochemistry, Sendai
Miyazaki F. (Graduate School of Science and Technology, Chiba University), Hashizume T. (Technology Department, Kazami Co., Ltd), Kodama H., Masada M. (Department of Bioresources Chemistry, Chiba University) et al.

2001 Nov. "A Descriptive Questionnaire-Based Study on the Use of Biobran (MGN3), in Chronic Fatigue Syndrome"
TOWNSEND LETTER for Doctors & Patients, No.220, November 2001
J. Kenyon

Jul. "Inhibitory effect of MGN-3 on the progress of atopic dermatitis in NC mice"
11^th International Congress of Immunology, Stockholm
Nonoyama S. and L. Lin (Tokyo Medical and Dental University)

Mar. "MGN-3, a Novel Antitumor agent"
92^rd Annual Meeting 2001 of American Association for Cancer Research, Louisiana
Uyemura K., Tachiki K., Ghoneum M., Makinodan T., Makhijani N. and D. Yamaguchi, Drew University of Medicine and Science, Los Angels, CA, Greater Los Angeles VA Healthcare System, Los Angels, CA, UCLA Medical School/ Greater Los Angeles Los Angeles VA Healthcare System, Los Angels, CA.

2000 Dec. "Natural Biological Response Modifier (MGN-3) Shown To Be Effective Against Tumor Cell Growth"
8^th International Congress on Anti-Aging & Biomedical Technologies, Las Vegas
M. Ghoneum

Nov. "Evaluation of Multiple Immunotherapies (including Arabinoxylan) Based on NK Cell Activity and CD4/CD8 Ratio in Cancer Patients"
The 3rd Annual Meeting of the Japanese Society for Complementary & Alternative Medicine & Treatment
Kihachiro Takahara (Nishi-Shinjuku Clinic), Motoyoshi Okitsu (Medical Corporation Sano Surgery Clinic), Hiromi Matsuura (Mitsubishi Kagaku Bio-clinical Laboratories, Inc.) et al.

Oct. "Inhibitory effects of MGN-3 (modified arabinoxylan from rice bran) on free radical"
59^th Annual Meeting of the Japanese Cancer Association, Yokohama
Saito T., Ohkami H., Tsukada K., Tazawa K., Namikawa H., Oida S., Koike J., Yatsuzuka M. (Toyama Medical and Pharmaceutical University), Masada M. (Chiba University) et al.

Jun. "The Effect of MGN-3 on Cisplatin and Adriamycin Induced Toxicity in the Rat"
American Society for Pharmacology and Experimental Therapeutics, Boston
Jacoby H., Wnorowski G. (Product Safety Lab.), Sakata K. (Creative Strategy, Inc.) et al.

Mar. "The Effect of MGN-3 on Cisplatin and Adriamycin Induced Toxicity in the Rat"
101^st Annual Meeting of the American Gastroenterological Association, San Diego
Jacoby H., Wnorowski G. (Product Safety Lab.), Sakata K. (Creative Strategy, Inc.) and H. Maeda (Daiwa Pharmaceutical Co., Ltd.)

1999 Dec. "Application of Modified Rice Bran Dietary Fiber to Diabetes and Taste Preference in Streptozotocin-Induced Diabetic Rats."
2^nd International Conference on Food Factors, Kyoto
Ohara I., Onai K. (Kobe Women's University) et al.

Dec. "Immunostimulation and Cancer Prevention"
7^th International Congress on Anti-Aging & Biomedical Technologies, Las Vegas
Ghoneum M. (UCLA/Drew University)

Dec. "Evaluation of MGN-3 (BioBran) with activation function of NK cell activity on Superoxide Scavenging Activity"
12^th Japanese Conference on Bio Therapy, Yokohama
Tazawa K., Namikawa H., Oida S., Ito K., Yatsuzuka M., Koike J. (Toyama Medical and Pharmaceutical University ), Masada M. (Chiba University) et al.

Sep. "Modified Rice Bran Improves Glucose Tolerance in NIDDM Adult Rats Given Streptozocin as Neonates"
Amrican College of Nutrition 40^th Annual Meeting, Washington DC
Ohara I., Onai K (Kobe woman's University) et al.

Jul. "A Study of Active Oxygen Scavenging Activity of MGN-3 (BioBran)"
Methods in Kampo Pharmacology, 5th Shirakaba-ko Symposium
Kenji Tazawa, Hirohide Namikawa, Naoko Oida, Kayoko Ito, Miki Yatsuzuka, Jun Koike, Masahiro Masada et al.

Jul. "Evaluation of MGN-3 (BioBran) on Superoxide Scavenging Activity."
6^th Japanese Conference on Cancer Prevention, Tokyo
Tazawa K., Namikawa H., Oida S., Ito K., Yatsuzuka M., Koike J. (Toyama Medical and Pharmaceutical University) et al.

Jul. "A Case in Which Rice Bran Arabinoxylan Was Used As A Supplemental Treatment When Curing Metastasis To Bones From Lung Cancer"
2^nd Conference of Japanese Association for Alternative, Complementary and Traditional Medicine (JACT), Tokyo
Sobajima T. (Hoshigaoka Welfare Annuity Hospital) et al.

1998 Dec. "NK Immunorestration of Cancer Patients by MGN-3, a Modified Arabinoxylan Rice Bran (Study of 32 patients followed for up to 4 years)."
6^th International Congress on Anti-Aging & Bio-Medical Technologies, Las Vegas
Ghoneum M., (UCLA/Drew University)

Dec. "Active oxgen radical scavenging activity of the plant polysaccharide processed foodstuff BioBran"
3^rdJapanese Society for Food Factors, Tokyo
Tazawa K. (Toyama Medical and Pharmaceutical University) et al.

Oct. "Immunopotentiation by utilization of MGN-3 tissue"
Congress on Anti-Aging Medicine in Nevada
Ghoneum M., (UCLA/Drew University)

Sep. "NK cell activity by MGN-3"
26^th Academy of Alternative Medicine of Cancer in LA
Ghoneum M., (UCLA/Drew University)

Aug. " Synergistic Effect of Modified Arabinoxylane (MGN-3) and Low Dose of Recombinant IL-2 Human NK Cell Activity and TNF-α Production "
American Academy of Anti - Aging Medicine, 1998 East Coast Conference, New Jersey
Ghoneum M. and A. Jewett (UCLA/Drew University)

Jun. "MGN-3 Immunotherapy for the Treatment of Cancer."
The First International Symposium on Disease Prevention by IP6 & Other Rice Components, Kyoto
Ghoneum M. (UCLA/Drew University) et al.

1997 Sep. "The Effect of MGN-3, An Arabinoxylan Compound, on Serum Lipid in Streptozotocin Induced Diabetic Rats."
38^thAmerican Meeting of Nutrition Annual Meeting, New York
Ohara I. (Kobe Women's University) et al.

1996 Jul "Anti-HIV activity by MGN-3 In Vitro."
11^th International AIDS Conference in Vancouver
Ghoneum M and N. Galal (UCLA/Drew University)

Jun "Effect of Human Natural Killer Cell Activity and Interferon-γ Synthesis in vitro."
ASBMB/ASIP/AAI JOINT MEETING in New Orleans
Ghoneum M and N. Galal (UCLA/Drew University)

Apr. "NK immunomodulatory function in 27 cancer patients by MGN-3, a modified arabinoxylan from rice bran."
87th Annual Meeting of the American Association for Cancer Research (AACR). Washington DC
Ghoneum M and N. Galal (UCLA/Drew University)

1995 Nov. "Immunomodulatory and Anti-Cancer Properties of (MGN-3), a modified xylose from rice bran, in 5 Patients with Breast Cancer."
American Association for Cancer Research Special Conference in Baltimore
Ghoneum M. (UCLA/Drew University)

Mar. Establishment of the extraction technology of a new physiologically active substance "MGN-3" in rice bran
The start of basic tests on MGN-3

1992 Apr. Development of a physiologically active substance started using basidiomycete

The start of co-research on immunopotentiate material with Dr. M. Ghoneum, UCLA/Drew University

● Ghoneum M. 1998. "Enhancement of human Natural Killer cell activity by Modified Arabinoxylan from Rice Bran (MGN-3)", INT.IMMUNOTHERAPY ⅩⅣ(2) pp.89-99.

● Ghoneum M. 1998. "Anti-HIV Activity in Vitro of MGN-3, an Activated Arabinoxylan from Rice Bran", Biochemical and Biophysical Research Communications, 243, pp.25-29.

● Ghoneum M. and J. Brown. 1999. "NK Immunorestoration of Cancer Patients by MGN-3, A Modified Arabinoxylan Rice Bran (Study of 32 Patients Followed for up to 4 years)", Anti-Aging Medical Therapeutics, Vol.Ⅲ, pp.217-226.

● Maeda H. 1999. "Immunopotentiation Effects of Rice Bran Arabinoxylan", Food Style 21, Vol. 3 No. 12, pp.56-58

● Ohara I., Onai K. and H. Maeda. 1999. "Modified Rice Bran, MGN-3, Improves Glucose Tolerance in NIDDM Adult Rats Given Streptozotocin as Neonates", Journal of the American College of Nutrition, Vol.18, No.5, Abstract 108,549.

● Ghoneum M. and A. Jewett. 2000. "Production of TNF-α and IFN-γ from Human Peripheral Blood Lymphocytes by MGN-3, a Modified Arabinoxylan from Rice Bran", Cancer Detection and Prevention, Vol. 24, Issue4, pp. 314-342.

● Jacoby H., Wnorowski G., Sakata K. and H. Maeda. 2000. "The Effect of MGN-3 on Cisplatin and Adriamycin Induced Toxicity in the Rat", Gastroenteology, Vol.118, No.4, 4962

● Ohara I., Tabuchi R. and K. Onai. 2000. "Effects of Modified Rice Bran on Serum Lipids and Taste Preference in Streptozotocin-Induced Diabetic Rats", Nutrition Research, Vol.20, No.1, pp.59-68.

● Tazawa K. et al. 2000. "Scavenging Activity of MGN-3 (Arabinoxylan from Rice Bran) with Natural Killer Cell Activity on Free Radicals", Biotherapy, vol.14, No.5, pp.493-495

● Endo Y. and H. Kanbayashi. 2003. "Modified Rice Bran Beneficial for Weight Loss of Mice as a Major and Acute Adverse Effect of Cisplatin", Pharmacology & Toxicology, 92, pp. 300-303.

● Ghoneum M. and S. Gollapudi. 2003. "Modified arabinoxylan rice bran (MGN-3 / Biobran) sensitizes human T cell leukemia cells to death receptor (CD95) - induced apotosis", Cancer Letters, 201, 41-49

● Kubo C. et al. 2001. "The basic study of arabinoxylan compound (MGN-3) on the activation of vital defence", Clinical and Research, Vol.78, No.1, pp.193-196

● Maeda H. 2003. "The food function of Modified Arabinoxylan from Rice Bran (MGN-3)", Packing of food, Vol.33, No.1, pp.45-53

● Tazawa K., Ichihashi K., Fujii T., Omura K., Anazawa M and H. Maeda. 2003. "The Orally Administration of the Hydrolysis Rice Bran Prevents a Common Cold syndrome for the Elderly People Based on Immunomodulatory Function", Journal of Traditional Medicine, vol.20, No.3, pp.132-141.

● Kaketani K. 2004. "A Case Where an Immunomodulatory Food was Effective in Conservative Therapy for Progressive Terminal Pancreatic Cancer", Clinical Pharmacology and Therapy, Vol.14, No.3, pp.237-279

● Kawai T. 2004. "One Case of a Patient with Umbilical Metastasis of Recurrental Cancer (Sister Mary Joseph's Nodule, SMJN) Who has Survived for a Long Time under Immunomodulatory Supplement Therapy", Clinical Pharmacology and Therapy, Vol.14, No.3, pp.281-288

● Okamura Y. 2004. "The Clinical Singificance of BioBran (Rice Bran Arabinoxylan Derivative) in the Immunotherapy for Cancer", Clinical Pharmacology and Therapy, Vol.14, No.3, pp.289-294

● Takahara K. et al., 2004. "The Life Prolongation and QOL Improvement Effect of Rice Bran Arabinoxylan Derivative (MGN-3, BioBran) for Progressive Cancer", Clinical Pharmacology and Therapy, Vol.14, No.3, pp.267-271

● Tsunekawa H., 2004. "Effect of Long-term Administration of Immunomodulatory Food on Cancer Patients Completing Conventional Treatments", Clinical Pharmacology and Therapy, Vol.14, No.3, pp. 295-302

● Ichihashi K. 2004. "Experience with Administration of BioBran in Patients with Chronic Rheumatism", Clinical Pharmacology and Therapy, Vol.14, No.4, pp. 459-463

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